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Test Code MONOCL-RUR* Monoclonal Protein Study, Random, Urine

Reporting Name

Monoclonal Protein Study, Random, U

Useful For

Diagnosing monoclonal gammopathies

Profile Information

Test ID Reporting Name Available Separately Always Performed
RPEU Protein Electrophoresis, Random, U No Yes
RIFXU Immunofixation, Random, U No Yes
PTCON Protein, Total, Random, U No Yes

Testing Algorithm

The following algorithms are available:

-Amyloidosis: Laboratory Approach to Diagnosis

-Multiple Myeloma: Laboratory Screening

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type


Ordering Guidance

The use of a random urine specimen is sufficient for identifying the presence or absence of a monoclonal immunoglobulin, but a 24-hour specimen is preferred for quantitating and monitoring the abnormality. See MPSU / Monoclonal Protein Study, 24 Hour, Urine.

Shipping Instructions

Refrigerate specimen during collection and send refrigerated.

Specimen Required


-Urine Container, 60 mL (T313)

-Sarstedt 5 mL Aliquot Tube (T914)

Submission Container/Tube: Plastic, 60-mL urine bottle and plastic, 5-mL tube

Specimen Volume: 50 mL

Collection Instructions:

1. Collect a random urine specimen.

2. Aliquot at least 25-mL of specimen into a plastic, 60-mL urine bottle and at least 1-mL of specimen into a plastic, 5-mL tube.

3. Label specimens appropriately (60-mL bottle for protein electrophoresis and 5-mL tube for protein, total).

Specimen Minimum Volume

25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 14 days
  Frozen  5 days
  Ambient  24 hours

Reference Values


No reference values apply to random urine.



The following fractions, if present, will be reported as mg/dL:


Alpha-1 globulin

Alpha-2 globulin

Beta globulin

Gamma globulin

Day(s) Performed

Protein, total: Monday through Sunday

Electrophoresis, protein; Immunofixation: Monday through Friday

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information




LOINC Code Information

Test ID Test Order Name Order LOINC Value
RMPSU Monoclonal Protein Study, Random, U In Process


Result ID Test Result Name Result LOINC Value
PTCON Protein, Total, Random, U 2888-6
32526 Immunofixation, Random, U 74666-9
607975 Albumin 6942-7
607976 Alpha-1 globulin 9734-5
606979 Immunofixation Flag, Random, U No LOINC Needed
607977 Alpha-2 globulin 38190-5
607978 Beta globulin 9744-4
607979 Gamma globulin 9745-1
33044 A/G Ratio 44293-9
33045 M spike 40661-1
33046 M spike 40661-1
33047 Impression 49299-1

Report Available

4 to 6 days

Method Name

PTCON: Turbidimetry

RPEU: Agarose Gel Electrophoresis

RIFXU: Immunofixation


If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.