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Test Code 6MAMM 6-Monoacetylmorphine (6-MAM), Confirmation, Meconium

Reporting Name

6-MAM Confirmation, M

Useful For

Detection of in utero heroin exposure up to 5 months before birth

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type


Ordering Guidance

For chain-of-custody testing, order MAMMX / 6-Monoacetylmorphine (6-MAM) Confirmation, Chain of Custody, Meconium.

Specimen Required

Supplies: Stool container, Small (Random), 4 oz (T288)

Container/Tube: Stool container

Specimen Volume: 1 g (approximately 1 teaspoon)

Collection Instructions:

1. Collect entire random meconium (newborn's first bowel movements) specimen.

2. Send specimen frozen.

Additional Information: When refrigerated, a significant percentage of 6-monoacetylmorphine (MAM) will convert to morphine in less than 24 hours.

Specimen Minimum Volume

0.3 g (approximately 1/4 teaspoon)

Specimen Stability Information

Specimen Type Temperature Time Special Container
Meconium Frozen 14 days

Reference Values


Positives are reported with a quantitative liquid chromatography-tandem mass spectrometry result.

Cutoff concentration: 5 ng/g

Day(s) Performed

Monday through Sunday

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


G0480 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
6MAMM 6-MAM Confirmation, M 29345-6


Result ID Test Result Name Result LOINC Value
31874 6-Monoacetylmorphine 29345-6
31875 Interpretation 69050-3

Report Available

2 days

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)


If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.