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Test Code FENR Fentanyl Screen with Reflex, Random, Urine

Useful For

Screening for drug abuse or use involving fentanyl, and confirmation of fentanyl if present in the screen

Profile Information

Test ID Reporting Name Available Separately Always Performed
FENS Fentanyl Screen, U Yes Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
FENTU Fentanyl w/metabolite Conf, U Yes No

Testing Algorithm

Testing begins with a screening assay. If the fentanyl screen is positive, then the liquid chromatography-tandem mass spectrometry confirmation with quantification will be performed at an additional charge.

Reporting Name

Fentanyl Screen w/Reflex, U

Specimen Type


Ordering Guidance

For situations where chain of custody is required, a Chain of Custody Kit (T282) is available. For chain-of-custody testing, order FENTX / Fentanyl with Metabolite Confirmation, Chain of Custody, Urine.


For monitoring therapeutic drug levels, order FENTS / Fentanyl, Serum.

Additional Testing Requirements

If urine creatinine is required or adulteration of the sample is suspected, the following test should also be ordered, ADULT / Adulterants Survey, Random, Urine.

Specimen Required

Supplies: Urine Tubes, 10 mL (T068)

Collection Container Tube: Plastic urine container

Submission Container/Tube: 10 mL tube

Specimen Volume: 5 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.

Specimen Minimum Volume

2.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 14 days
  Frozen  14 days
  Ambient  72 hours

Reference Values


Screening cutoff concentration: 2 ng/mL

Day(s) Performed

Monday through Saturday

Report Available

Same day/1 to 2 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
FENR Fentanyl Screen w/Reflex, U 59673-4


Result ID Test Result Name Result LOINC Value
63060 Fentanyl Screen, U 59673-4

Method Name



If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.