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Test Code FET Iron, Liver Tissue

Reporting Name

Iron, Liver Ts

Useful For

Diagnosis of hemochromatosis using liver tissue specimens

Testing Algorithm

For information see Hereditary Hemochromatosis Algorithm

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Liver Tissue

Necessary Information

Patient's date of birth is required to calculate iron index.

Specimen Required

Supplies: Metal Free Specimen Vial (T173)


Preferred: Mayo metal-free specimen vial (blue label)

Acceptable: Paraffin block, if not more than 1 or 2 cuts have been made to it for slides

Specimen Volume: 2 mg

Collection Instructions:

1. Two mg of liver tissue is required. This is typically a piece of tissue from a 22-gauge needle biopsy at least 2 cm long. If an 18-gauge needle is used, the tissue must be at least 1 cm in length.

2. Any specimen vial other than a Mayo metal-free vial used should be plastic, leached with 10% nitric acid for 2 days, rinsed with redistilled water, and dried in clean air.

Additional Information: Paraffin blocks will be returned 3 days after analysis is complete.

Specimen Minimum Volume

2 cm (22-gauge needle)
1 cm (18-gauge needle)
2 mm x 2 mm (punch) 0.3 mg by dry weight

Specimen Stability Information

Specimen Type Temperature Time Special Container
Liver Tissue Refrigerated (preferred)

Reference Values


Males: 200-2,400 mcg/g dry weight

Females: 200-1,800 mcg/g dry weight



≥13 years: <1.0 mcmol/g/year

Reference values have not been established for patients that are younger than 13 years of age.

Day(s) Performed

Monday, Wednesday, Friday

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
FET Iron, Liver Ts 57028-3


Result ID Test Result Name Result LOINC Value
8350 Iron, Liver Ts 57028-3
7770 Hepatic Iron Index 49061-5

Report Available

3 to 5 days

Method Name

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)