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Test Code HTG2 Thyroglobulin, Tumor Marker, Serum

Useful For

Follow-up of patients with differentiated thyroid cancers after thyroidectomy and radioactive iodine ablation

Testing Algorithm

All specimens are screened for the presence of autoantibodies to thyroglobulin.

Reporting Name

Thyroglobulin, Tumor Marker

Specimen Type

Serum Red

Ordering Guidance

For accurate analysis of patients who are known to be thyroglobulin antibody positive, order TGMS / Thyroglobulin Mass Spectrometry, Serum.

Specimen Required

Patient Preparation: For 12 hours before specimen collection do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.

Collection Container/Tube: Red top (serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 7 days
  Frozen  30 days

Reference Values


Athyrotic: <0.1 ng/mL

Intact thyroid ≤33 ng/mL



<1.8 IU/mL

Reference values apply to all ages.

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information



LOINC Code Information

Test ID Test Order Name Order LOINC Value
HTG2 Thyroglobulin, Tumor Marker 57780-9


Result ID Test Result Name Result LOINC Value
TGAB2 Thyroglobulin Antibody, S 56536-6
HTGN2 Thyroglobulin, Tumor Marker, S 3013-0
HTG2I Thyroglobulin Interpretation 69053-7

Method Name

Immunoenzymatic Assay


If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-General Request (T239)

-Oncology Test Request (T729)