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Test Code THYR-STIM* Thyroid-Stimulating Immunoglobulin, Serum

Additional Codes

Mayo Test ID

Reporting Name

Thyroid-Stimulating Immunoglob, S

Useful For

Second-order testing for autoimmune thyroid disease, including:

-Differential diagnosis of etiology of thyrotoxicosis in patients with ambiguous clinical signs or contraindicated (eg, pregnant or breast-feeding) or indeterminate thyroid radioisotope scans

-Diagnosis of clinically suspected Graves disease (eg, extrathyroidal manifestations of Graves disease: endocrine exophthalmos, pretibial myxedema, thyroid acropachy) but normal thyroid function tests

-Determining the risk of neonatal thyrotoxicosis in a fetus of a pregnant female with active or past Graves disease

-Differential diagnosis of gestational thyrotoxicosis versus first-trimester manifestation or recurrence of Graves disease

-Assessing the risk of Graves disease relapse after antithyroid drug treatment


A combination of TSI / Thyroid-Stimulating Immunoglobulin, Serum and THYRO / Thyrotropin Receptor Antibody, Serum is useful as an adjunct in the diagnosis of unusual cases of hypothyroidism (eg, Hashitoxicosis).

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type


Ordering Guidance

This test is used for second-order testing for autoimmune thyroid disease.

For suspected cases of autoimmune hypothyroidism, the first-order testing is TPO / Thyroperoxidase Antibodies, Serum.


For suspected cases of autoimmune thyroid disease, first-order testing includes TPO and THYRO / Thyrotropin Receptor Antibody, Serum.

Specimen Required

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Specimen Minimum Volume

0.1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Frozen (preferred) 60 days
  Refrigerated  7 days
  Ambient  24 hours

Reference Values

≤1.3 TSI index

Reference values apply to all ages.

Day(s) Performed

Monday through Friday

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
TSI Thyroid-Stimulating Immunoglob, S 30567-2


Result ID Test Result Name Result LOINC Value
8634 Thyroid-Stimulating Immunoglob, S 30567-2

Report Available

2 to 6 days

Method Name

Recombinant Bioassay


If not ordering electronically, complete, print, and send a General Request (T239) with the specimen.