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Test Code THYROTR* Thyrotropin Receptor Antibody, Serum

Additional Codes

Mayo Test ID

Reporting Name

Thyrotropin Receptor Ab, S

Useful For

Recommended first-line test for detection of /thyrotropin receptor antibodies


The following situations:

-Differential diagnosis of etiology of thyrotoxicosis in patients with ambiguous clinical findings and/or contraindicated (eg, pregnant or breast-feeding) or nondiagnostic thyroid radioisotope scans

-Diagnosis of clinically suspected Graves disease (GD) (eg, extrathyroidal manifestation of GD include endocrine exophthalmos, pretibial myxedema, thyroid acropachy) in patients with normal thyroid function tests

-Determining the risk of neonatal thyrotoxicosis in a fetus of a pregnant female with active or past active GD

-Differential diagnosis of gestational thyrotoxicosis versus first trimester manifestation or recurrence of Graves’ disease

-Assessing the risk of GD relapse after antithyroid drug treatment

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type


Specimen Required

Patient Preparation:

1. For 12 hours before specimen collection do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.

2. Patient should not be receiving heparin treatment.


Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 1 mL

Specimen Minimum Volume

0.75 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 7 days
  Frozen  30 days

Reference Values

≤1.75 IU/L

Day(s) Performed

Monday through Friday

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
THYRO Thyrotropin Receptor Ab, S 5385-0


Result ID Test Result Name Result LOINC Value
THYRO Thyrotropin Receptor Ab, S 5385-0

Report Available

1 to 3 days

Method Name

Electrochemiluminescence Immunoassay


If not ordering electronically, complete, print, and send a General Request (T239) with the specimen.