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Test Code TYRSC Tyrosinemia Follow-Up Panel, Self-Collect, Blood Spot


Necessary Information


1. Patient's age is required.

2. Patient's street address, city, state, ZIP (postal) code, country, and home phone are required (post-office (PO) boxes are not acceptable delivery locations).



Specimen Required


Supplies: Blood Spot Collection-Self Collect (T858)

Container/Tube: Blood Spot Self Collection Card

Specimen Volume: 2 Blood spots

Additional Information:

1. Order test each time the patient is to collect a dried blood specimen at home and mail the specimen directly to Mayo Clinic Laboratories.

2. Order should be placed a minimum of 3 days prior to desired date of collection.

3. Enter patient's address information for each order created, including street address (post-office (PO) boxes are not acceptable delivery locations), city, state abbreviation, zip code, country, and home phone number.

4. For each order, the Blood Spot Collection-Self Collect kit will be mailed directly to the patient for self-collection (delivery to a PO box will not occur).

5. See Dried Blood Spot Collection Tutorial for how to collect blood spots.


Useful For

Monitoring of individuals with tyrosinemia type I (hepatorenal tyrosinemia)

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Tyrosinemia Follow Up Panel, SC, BS

Specimen Type

Whole blood

Specimen Minimum Volume

1 Blood spot

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole blood Ambient (preferred) 90 days FILTER PAPER
  Frozen  90 days FILTER PAPER
  Refrigerated  90 days FILTER PAPER

Reference Values

TYROSINE

<4 weeks: 40.0-280.0 nmol/mL

≥4 weeks: 25.0-150.0 nmol/mL

 

PHENYLALANINE:

27.0-107.0 nmol/mL

 

METHIONINE:

11.0-45.0 nmol/mL

 

SUCCINYLACETONE:

<1.00 nmol/mL

 

NITISINONE:

<0.7 nmol/mL

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

84510

84030

82131

82542

80299

82542 only (if appropriate for government payers)

 

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TYRSC Tyrosinemia Follow Up Panel, SC, BS 94573-3

 

Result ID Test Result Name Result LOINC Value
610503 Tyrosine 35571-9
610504 Phenylalanine 29573-3
610505 Methionine 47700-0
610506 Succinylacetone 53231-7
610507 Nitisinone 85098-2
BG728 Reason for Referral 42349-1
610502 Reviewed By 18771-6
BG729 Patient Street Address 56799-0
BG730 Patient City 68997-6
BG731 Patient State 46499-0
BG732 Patient Zip Code 45401-7
BG741 Patient Country 77983-5
BG733 Patient Home Phone 42077-8

Day(s) Performed

Monday through Friday

Report Available

3 to 5 days